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Premature Birth

From DES to Makena and More: The Dangers of Endocrine Disruptors

On this day, half a century ago, a study showed that a drug called diethylstilbestrol (DES) given to pregnant mothers to reduce preterm births, instead raised the risk of a rare vaginal cancer in their daughters to 40 times that of the general population. Since then, scientists have discovered that…

Makena Found Not Effective at Reducing Premature Birth

In a surprise result, a study of a drug designed to lower the risk of premature birth was shown to be no better than a placebo. Update, October 30, 2019 An FDA Advisory Committee met to review Makena (17-α hydroxyprogesterone injection or 17-OHPC) in light of the new post-approval study…