Statins
Doctors prescribe statins to lower cholesterol and reduce the risk of heart disease. Here are pros and cons to consider when taking them. Common Names Lipitor (atorvastatin), Crestor (rosuvastatin), Zocor (simvastatin), Pravachol (pravastatin), Mevacor (lovastatin), Lescol (fluvastatin), Livalo (pitavastatin), Altoprev (lovastatin extended release) Side Effects and What to Do About…
Statins have been associated with a host of side effects. Based on observational studies, as many as 30% of those taking the medications experience muscle aches and pains. There is also some evidence statins may boost the risk of developing diabetes.
About half of people prescribed statin medications fail to achieve an appropriate reduction in LDL (“bad”) cholesterol levels two years after taking the drug. Researchers in the UK examined data on more than 165,000 people prescribed a statin between 1990 and 2016. They had not been treated for a heart…
Elderly nursing home patients prescribed a multitude of medications following a heart attack may live longer compared to those given just one drug, but it can come at a cost: It may negatively impact their quality of life. Researchers examined claims data from nearly 4,800 nursing home residents, most of…
Over my career as a pharmacist, I’ve been very conscientious about filling prescriptions accurately as prescribed. I’ve also made it a priority to focus on counseling patients on how to take their medications properly and informing them of potential side effects to look out for. Now that I’m on the…
Although statins are a mainstay of treatment for high cholesterol, many people who take the drugs experience side effects. But a new drug appears to lower the body’s “bad” cholesterol levels, but without side effects, such as muscle pains, seen with statins. The new drug, bempedoic acid, works by targeting…
Numerous medicines have been shown to increase the risk of liver damage and liver failure
Statins are used to lower cholesterol, but some people have side effects or don’t want to take meds. Find out about alternatives and their effectiveness. More than 30 years have passed since the first cholesterol-busting statin drug hit the market in the United States, and the medications remain blockbusters. If…
If you have high cholesterol and cardiovascular risk factors, you may be prescribed a statin. Should you be concerned about the risks of these drugs? Seems my doctor wants me to take one too. I had my annual check-up with my physician a few weeks ago and was disappointed when…
The benefits of statin medications outweigh their risks, the American Heart Association says, responding to a study that came out last week that argued the cholesterol-lowering drugs are overprescribed. The AHA said that about 10% of Americans on a statin stop taking it because of side effects that they believe…
A new study is arguing that statins may be overprescribed since in many people, the risks of the cholesterol-lowering drugs outweigh their benefits. Current US guidelines recommend that statins be prescribed to those who have a 10% risk of having a heart attack within the next 10 years and who…
Almost half of patients 65 and over that are prescribed statins stop taking them within a year — and side effects may be to blame. Researchers looked at 22,340 seniors who started statin therapy and found that 45% stopped taking the medication within a year of receiving the prescription. Results…
New research is casting doubt on the benefits of statin medications beyond reducing the risk of cardiovascular events. Statins, such as Lipitor (atorvastatin) and Crestor (rosuvastatin), are commonly prescribed cholesterol-lowering drugs that can help to reduce the risk of having a heart attack or stroke. Some studies had indicated that…
A type of statins, drugs which are used to lower cholesterol, may increase the risk for memory loss and other cognitive issues, according to a new study. The drugs in question are known as lipophilic statins. Common ones are Lipitor (atorvastatin), Zocor (simvastatin) and Mevacor (lovastatin). Compared to other types…
Statin drugs that lower cholesterol and reduce the risk of heart attacks and strokes are among the most-prescribed drugs in the U.S. About 28% of people aged 40 and over take one. That number rises to 50% of people aged 75 and over. The evidence is overwhelming that statins work:…
Other methods to lower cholesterol may be just as effective as statins in also reducing cardiovascular events. Researchers recently analyzed 49 trials involving more than 300,000 people that looked at different ways of lowering cholesterol. The trials were sorted into 4 groups: Those that examined statins; nonstatin treatments that work…
People who stopped taking statins because of side effects such as muscle aches or stomach pain were found to be slightly more likely to die or have a heart attack or stroke according to a new study. The study, published in the Annals of Medicine found that people who continued…
The solution to a lifetime of statins could lie in a diet based on vegetables, whole grains, beans and fruit. The medical community recommends statins as a front-line (first-choice) treatment for high cholesterol levels that may also cut your chances of having a heart attack. Yet studies show that other…
Statins, which are widely used to lower cholesterol, may end up accelerating the onset of Parkinson’s disease in some patients. Researchers at Penn State College of Medicine examined insurance claims data from 50 million people. They found 22,000 people that were diagnosed with Parkinson’s, though only 2,322 were newly diagnosed….
New evidence indicates that doctors may want to think twice before prescribing a statin to seniors with no history of heart disease for prevention of heart attack. A new study finds that the cholesterol-lowering medication does not appear to reduce that risk, and the mortality rate was higher in those…
Adverse events such as muscle pain and weakness that some people taking statins claim may be overblown and are the result of a “nocebo” effectshaping people’s negative opinion about a drug. Researchers in the UK say a new study they conducted shows that people are much more likely to say…
Use of a common class of drugs used to lower cholesterol may increases one’s risk of developing back problems. Researchers examined data on 14,000 adults more than 30 years old who were enrolled in TRICARE, the military’s health care program. Half had taken a statin drug an average of 3.7…
Two commonly prescribed cholesterol-lowering drugs taken along with a blood thinner used by patients with an irregular heartbeat may significantly increase the risk for internal bleeding. Mevacor (lovastatin) and Zocor (simvastatin) are two popular statins, a class of drugs used by millions of Americans to lower cholesterol. Pradaxa (dabigatran) is…
Just-issued guidelines from the U.S. Preventive Services Task Force’s (USPSTF) could greatly expand the number of people taking the cholesterol-lowering drugs known as statins. However, some doctors are criticizing the more aggressive position, citing concerns about side effects and the efficacy of the medications. The USPSTF is now recommending that…
Doctors and patients need to be aware of drug-drug interactions between medications used to lower cholesterol and those used to treat heart disease, according to new recommendations from the American Heart Association (AHA). Statins, which are used to lower cholesterol, are among the most popular drugs prescribed to American adults….
Other methods to lower cholesterol may be just as effective as statins in also reducing cardiovascular events. Researchers recently analyzed 49 trials involving more than 300,000 people that looked at different ways of lowering cholesterol. The trials were sorted into 4 groups: Those that examined statins; nonstatin treatments that work…
High blood pressure and heart disease meds, statins, dairy and Coumadin can all have bad interactions with certain drugs. Make sure you’re not blocking the effectiveness of your meds with your food.
The benefits of using the cholesterol-lowering drugs known as statins greatly outweigh any risks associated with them, as side-effect rates have been greatly exaggerated, according to a new analysis of studies. The review does concede that serious side effects can be caused by long-term statin use. These include muscle pain…
Is your cholesterol high? Has your doctor suggested you might be at risk for heart disease? If so, you have some decisions to make. You need to know that you can likely improve your health and lower your cholesterol by simple lifestyle changes like exercise and changing your diet. You…
Eating a Mediterranean-style diet — one that is rich in fish, olive oil, nuts and vegetables — may be more effective at cutting the risk of death in people with cardiovascular disease than statins — and without the side effects. Findings, presented at the European Society of Cardiology Congress in…
Many commonly used medications can lead to heart failure or worsen existing heart failure, according to a scientific statement from the American Heart Association (AHA). Many of the drugs that the AHA identified increase heart failure risk due to their high sodium content. Some of these drugs are: Fosamax (alendronate),…
Doctors prescribe statins to lower cholesterol. Here are upsides and downsides to consider when taking them. Common Names Lipitor (atorvastatin), Crestor (rosuvastatin), Zocor (simvastatin), Pravachol (pravastatin), lovastatin (Mevachol), Lescol (fluvastatin), Altoprav (lovastatin), Livalo (pitavastatin) Side Effects and What to Do About Them Muscle Aches and Pains: Based on observational studies,…
If a doctor insists on prescribing you a brand-name drug even if there is a generic version available, it may be because he or she is getting a kickback from a pharmaceutical company to do so. Harvard Medical School researchers examined the prescribing rates of statins, the popular cholesterol-lowering drug,…
The link between statins and muscle pains reported by people taking them will be analyzed in a major new trial led by the London School of Hygiene & Tropical Medicine. The Statin WISE trial, which started last month, involve 200 participants who have recently either stopped taking statins due to…
Does it really make sense to put a large group of people on a drug whose effectiveness hasn’t been proven for that group? What at first looked like a creeping increase in statin prescriptions is turning into a gallop. Despite the significant and life-altering side effects that this class of…
Two studies suggest that statin use decreases the effect of the flu vaccine, according to findings published in The Journal of Infectious Diseases. One of the reports shows that many senior statin users had a significantly reduced immune response to the vaccination, compared with those not taking statins. In the…
In a cohort study of statin-treated patients and nontreated controls, Cardwell et al concluded that statin treatment may prevent colon cancer. However, a recent study showed that 10 years of statin therapy increased women’s risk of invasive ductal carcinoma (most common type of breast cancer) by 83% and their risk…
The healthcare informatics company, Advera Health Analytics, sifted through FDA postmarketing safety reports, and compiled data on side effects for companies producing statin drugs. Advera’s report found that Merck’s Zocor, Mevacor and Vytorin were associated with more muscle-related side effects than other drugs in the class such as Pfizer’s Caduet,…
Researchers, from Radboud University Nijmegen Medical Center in the Netherlands, discovered 25% of patients taking statins had unpleasant side effects in the form of muscle weakness, pain and cramps, without any sign of damage to the tissue. Research suggests that muscle weakness and related side effects that can arise from…
Six commonly used drugs—statins, antacids, oral contraceptives, antidepressants, diabetes drugs and antibiotics—can have serious side effects. These drugs can deplete the body of certain nutrient levels and lead to chronic diseases. Via Medical Daily. Posted August 6, 2015. –Alanna McCatty
A study examining the effects of statin therapy on levels of aggression suggests that men and women may respond differently to the lipid-lowering medications. A University of California San Diego Statin Study included 1016 adults undergoing randomization to placebo, simvastatin, or pravastatin for 6 months. In women, treatment with statin…
Have you heard of PCSK9 inhibitors? If you read our FDA Watch post about them, you know that this new class of medication just received preliminary FDA approval as a cholesterol-lowering agent. In a 2015 study published in the New England Journal of Medicine, participants taking PCSK9 inhibitors had LDL…
Researchers from Duke University School of Medicine recruited 381 people who were not expected to live for more than a year. About half the participants were randomly assigned to stop taking statins. According to researchers, the group that stopped taking the drugs did have a small improvement in their quality…
Statins may increase the risk of diabetes by a considerable amount. In a study published in Diabetologia, scientists from Finland found that men who were prescribed statins to lower their cholesterol had a 46% greater chance of developing diabetes after six years compared to those who weren’t taking the drug….
A new analysis has shown that 1 in 5 patients with coronary artery disease receiving a statin failed to have a significant LDL (low-density lipoprotein)-lowering response to treatment. These patients experienced a significant progression of atherosclerosis (plaque build up inside the arteries) over a follow-up period ranging from 18 to 24 months….
Previously, studies have found that the cholesterol-lowering medications statins may offer protective benefits against Parkinson’s disease. However, a new study led by researchers at Penn State College of Medicine and the National Institute of Environmental Health Sciences found an increased long-term risk of Parkinson’s disease among statin users. Via Medical…
Oxford professor plans to study thousands of patient records to discover how many may have suffered issues. Sir Rory Collins of Oxford University has previously carried out studies showing that prescribing statins more widely could save lives and prevent 10,000 heart attacks and strokes. However, he has acknowledged that his earlier…
In a new study, Canadian researchers looked at more than 104,000 people aged 66 and older who were taking one of two common antibiotics — Biaxin or Zithromax — along with one of three statins: rosuvastatin, pravastatin or fluvastatin. People who used Biaxin plus one of the statins had a…
Statins do not reduce risk of osteoporotic fractures, a prespecified secondary analysis of the JUPITER trial determined. The study included 17,802 men and women with no history of atherosclerosis. The mean age was 66. During the study, 221 incident fractures occurred in the participants on rosuvastatin and 210 occurred in…
A study, published in the Canadian Journal of Cardiology, looked at more than 207,000 adults with cataracts and more than 1.1 million without them. Those who took statins for at least a year had about a 27% increased risk of developing cataracts that needed surgery, compared with people not taking…
The regular use of statins, particularly among women, was associated with an increased risk of thyroid cancer, Taiwanese researchers reported. Compared with controls, patients who routinely used statins had an adjusted odds ratio for having thyroid cancer of 1.40 according to Shiu-Dong Chung, MD, of Far Eastern Memorial Hospital in…
A study led by researchers at Queen Mary University of London found two new common genetic variants in 40,000 individuals which significantly affected the degree to which bad cholesterol was lowered during statin treatment. A followup study of a further 22,318 individuals confirmed the findings. One of the identified genetic…
I urge everyone to listen to this BBC Radio 4 interview conducted by a persistent female News Presenter, as they’re called in the UK, and Professor Mark Baker, the director of the UK’s drug-regulatory organization. The presenter’s bold and naive-sounding questions are exactly the questions that should be asked, and Professor…
People in the late stages of cancer and other terminal illnesses are not only unharmed by discontinuing statins for cholesterol management, they may benefit, according to a new study. The research team enrolled 381 patients who faced the likelihood of dying within a year. Among the 192 study patients who…
A new study suggests that older men taking the cholesterol-lowering drugs known as statins appear to be slightly less active than those who do not take them. According to the study, statin users logged about 40 fewer minutes of moderate activity each week compared to nonusers. These findings confirm those…
When Beverly Wilkerson, 58, Sherman Oaks, CA, woke up with a pounding headache and jaw pain last summer, she popped two Aleve. (The recommended dosage is one at a time.) She forgot to take water and food with the pills. Later on, she took two more, again forgetting the water…
I’m confused about who should take statins when. And frankly, I think the medical community is too. This worries me. It defies logic that more than 40% of men and 20+% of women would need to take a drug every day. Are we all sick? Certainly nature did not intend…
A study of patient records in the military health care system over a 9-year period has found a correlation between statin use and cataracts. This does not prove that statins caused cataracts. However, those on statins were 27% more likely to develop cataracts. JAMA Opthamology via Philly.com In a completely…
Are depression or violent actions side effects of statins? via: MPR (Monthly Prescribing Reference.
Very important – If you are taking statins, avoid erythromycin and chlarithromycin. Both can increase the concentration of statin in your blood stream, leading to muscle or kidney damage, possibly death. If you need an antibiotic, use azithromycin instead. From WebMD –MedShadow Staff
It’s not easy being a consumer. The information available to the public is often contradictory and confusing. For example, take the issue of statins (Lipitor, Crestor, Zocor, etc.). There are many known side effects of statins, some beneficial, some not so much. When reading on-line discussions of statin side effects,…
The British Medical is reporting on a study that links high potency statins with acute kidney injury. The Canadian studyconcludes that the “use of high potency statins is associated with an increased rate of diagnosis for acute kidney injury in hospital admissions compared with low potency statins. The effect seems…
Women with breast cancer, undergoing anthracycline chemo, have a significantly lower rate of heart problems in a retrospective study published in Journal of American College of Cardiology, December 2012. Link here to report on Breastcancer.org.
New research indicates long-term use of statin may reduce the risk of brain and spine tumors, called glioma. (Wikipedia: a glioma is a type of tumor that starts in the brain or spine. It is called a glioma because it arises from glial cells. The most common site of gliomas is the brain. Gliomas…
