Ozempic, Wegovy, Rybelsus. These brand-name medications all contain semaglutide, a glucagon-like peptide-1 (GLP-1) agonist. Collectively, GLP-1 drugs can help treat a wide range of medical conditions, from diabetes to obesity.
According to a 2025 poll from the health policy information organization KFF, about 1 in 8 U.S. adults have taken GLP-1s at some point in their lives. If that includes you, and you find yourself having a drink every now and then, it’s helpful to know that moderate alcohol use has been shown to be safe for most people taking Ozempic and similar drugs.
Still, mixing medications with alcohol always comes with risks.
Ozempic and Alcohol Interaction: What’s the Risk?
Drinking alcohol while taking Ozempic is generally safe, says Marc-Andre Cornier, M.D., director of Endocrinology, Diabetes, and Metabolic Diseases at the Medical University of South Carolina. “There’s no known direct interaction between GLP-1s and alcohol,” he explains.
However, there may be reasons to limit alcohol use if you take Ozempic. Here’s what to watch for:
- Digestive problems affect many people taking GLP-1 drugs. In a study of more than 3,000 people using semaglutide 2.4 mg weekly for weight loss, over 40% reported nausea. In type 2 diabetes studies, up to 20% of people taking Ozempic 1 mg weekly injections experienced nausea. Though digestive issues are usually mild to moderate and improve on their own over time, drinking alcohol can also cause them to worsen. So consider cutting back if you experience these GLP-1 side effects.
- Dehydration can result from vomiting or diarrhea caused by GLP-1s. It’s important to stay hydrated while taking these medications, notes Dr. Cornier, especially if you drink alcohol, which can also dehydrate you.
- Low blood glucose (sugar), or hypoglycemia, is rare with Ozempic and other GLP-1s when taken alone. But if you’re prescribed insulin or other diabetes medications known to lower blood glucose, and/or drink alcohol, your risk goes up. So be sure you know how to recognize and treat hypoglycemia.
- Pancreatitis, or inflammation of the pancreas, is a painful and serious disease. Heavy, long-term alcohol use can lead to pancreatitis. This condition has also been associated with Ozempic and other GLP-1s (though rare). However, recent research has questioned whether the link between these medications and pancreatitis truly exists.
- Weight gain from alcohol use is possible. Alcohol adds calories to your diet, makes you more likely to eat unhealthy foods, and may change the way your body burns fat. So if you’re trying to lose weight with GLP-1s, it’s best to limit the amount of alcohol you drink, says Dr. Cornier.
This guidance also applies to Mounjaro and Zepbound. These medications contain the active ingredient tirzepatide, which works similarly to semaglutide and other GLP-1s.
Can Ozempic Reduce Your Desire to Drink Alcohol?
It’s possible. Semaglutide and tirzepatide may reduce alcohol intake in some adults taking these medications for obesity (without diabetes). But more research is needed before any conclusions can be made. Still, Dr. Cornier notes he sees this with his patients. “They’re telling me they used to drink a glass of wine at night and now they don’t feel like it anymore,” he says.
Semaglutide is also being studied for the treatment of alcohol use disorder (AUD). Anil Makam, M.D., an internal medicine physician at the University of California, San Francisco, notes that GLP-1s may be a future therapeutic option for people with substance use disorders. “There’s a lot of promise for these medications in treating AUD, but we don’t have enough research yet to know for sure,” he says.
Safety Tips for Alcohol Use While on Ozempic
If you’re taking Ozempic, Mounjaro or other GLP-1 drugs, you can drink the occasional glass of wine or cocktail more safely with these tips:
- Know the risks of alcohol. While most alcohol use is generally acceptable for people taking GLP-1s, the World Health Organization stresses that no amount of alcohol is safe for our health. If you do choose to drink alcohol, keep it in the low-to-moderate range. Moderate use is typically defined as one drink or less in a day for women and two drinks or less a day for men.
- Stay hydrated. Since both Ozempic and alcohol can cause dehydration, keeping up your fluid intake is important.
- Monitor your blood glucose levels. If you take a GLP-1 for diabetes, make sure you understand how often to monitor your blood sugar levels, especially if you drink alcohol.
