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Home > Drug Safety > Drug Cascades

Drug Cascades

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October 8, 2025 (Updated on: October 27, 2025)
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Also known as “prescribing cascades,” drug cascades occur when a medication is prescribed to treat the side effects of an original drug you are on.

For example, a person might be prescribed a nonsteroidal anti-inflammatory (NSAID) to help relieve arthritis pain. A common side effect of NSAIDs is acid reflux. The person is then prescribed a proton pump inhibitor like omeprazole to treat the refux.

While drug cascades are sometimes considered appropriate when the benefits outweigh the risks, they can also lead to compounded side effects, drug-to-drug interactions, and worsened conditions over time.

DISCLAIMER: MedShadow provides information and resources related to medications, their effects, and potential side effects. However, it is important to note that we are not a substitute for professional medical advice, diagnosis, or treatment. The content on our site is intended for educational and informational purposes only. Individuals dealing with medical conditions or symptoms should seek guidance from a licensed healthcare professional, such as a physician or pharmacist, who can provide personalized medical advice tailored to their specific circumstances.

While we strive to ensure the accuracy and reliability of the information presented on MedShadow, we cannot guarantee its completeness or suitability for any particular individual’s medical needs. Therefore, we strongly encourage users to consult with qualified healthcare professionals regarding any health-related concerns or decisions. By accessing and using MedShadow, you acknowledge and agree that the information provided on the site is not a substitute for professional medical advice and that you should always consult with a qualified healthcare provider for any medical concerns.

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