INVESTIGATING GENERICS: Real People Share Their Struggles With Generic ADHD Medications

Since MedShadow began publishing our investigative series on quality issues with generic ADHD medications, thousands of people have commented on our TikTok account about their own experiences, and many others have sent emails detailing how inconsistent medications have disrupted their daily lives.

One key study we highlighted in the series found major differences in how quickly extended-release methylphenidate (the generic version of Concerta) dissolved depending on the manufacturer. This validated what many patients have long reported — that their medication was not delivering the appropriate dose during the expected time period, leaving them unable to complete certain tasks and forcing them to structure their days around brief windows of productivity. We also shed light on records of recalls of generic Vyvanse that contained pills with inconsistent doses or that were labeled as the wrong dose. Healthcare providers told MedShadow they regularly encounter these problems in their own practice.

The central takeaway from our series is clear: these problems are real. After our initial reporting, even more people stepped forward with accounts of how low-quality medications have disrupted their lives. Here’s what they told us, in their own words. [We’ve only used first names to protect medical privacy.]

Ashley

Diagnosis: ADHD
ADHD Stimulant Prescribed: Adderall

In college, Ashley began having so much trouble paying attention in class that she would have to record her lectures and then spend five hours listening to a one-hour class. “I would have to rewind them over and over and over again, because I would catch myself just not listening,” she says.

When she saw her doctor in October of 2020, he prescribed her extended-release Adderall (amphetamine/dextroamphetamine salts). She started taking a generic version made by Lanette. “It was great for me,” she says, until the middle of 2022, when the stimulant drug shortages began. That’s when she believes her medication stopped working the same way.

Ashley says she began to notice it was taking her much longer to get ready for work in the mornings than it had before. In the past, she’d take 30 seconds to choose an outfit after taking her medication. But during the middle of 2022, Ashley says she would walk to her closet and just stare at her clothes. “I didn’t know where to start,” she says. “Instead of taking me 30 minutes from waking up to getting out the door, it was taking me an hour and a half.”

She found herself wondering, “Did I really take my medication today?” Eventually, she began using weekly pill organizers marked by day, so she could confirm she had taken it, even though it didn’t feel like it was working.

When she told her doctor in January of 2023 that she suspected her medication was no longer working, her doctor suggested she had depression and prescribed Zoloft to be taken alongside her ADHD medication. Ashley didn’t take the Zoloft. She maintains that any symptoms of depression were a result of her ADHD symptoms returning and depleting her energy.

In February of that year, her primary care doctor referred her to a new ADHD clinic. The providers there adjusted her dose of extended-release Adderall, and added an immediate-release Adderall to her regimen.

Since then, Ashley has often faced the problem of receiving pills from different manufacturers in the same bottle. On one occasion, her prescription contained 20 capsules from one manufacturer and 10 from another. The pharmacy explained that they filled what they could with one manufacturer, then gave her the rest of the 30 days from another. According to Ashley, pills from one manufacturer worked notably better than the other — even though they were all in the same bottle.

Today, Ashley continues to take extended-release generic Adderall. She’s tried different doses and says sometimes they seem to work, sometimes they don’t. For example, after a refill in January 2025 from the manufacturer Mallinckrodt, Ashley says the side effects were “by far the worst” she had ever experienced. She says she felt flushed, constipated, irritable, and exhausted. She even experienced headaches and a hive-like rash, which prompted her to fill out a MedWatch report.

Shannon

Diagnosis: ADHD
ADHD Stimulants Prescribed: Adderall and Vyvanse

Fourteen years ago, when Shannon was 27, she was diagnosed with ADHD and prescribed generic Adderall. “It worked,” she says. But after two years, she stopped taking the medication. She’d gotten sober [editor’s note: ADHD is associated with an increased risk of substance use disorders], and the sober communities she was a part of frowned upon the use of stimulant medication.

Last year, Shannon told her doctor she was having extreme mood swings. She tried therapy and antidepressants with little success, but because Adderall had helped her in the past, her doctor decided to prescribe the generic version.

“It was completely different this time,” Shannon says, remembering falling asleep two hours after taking the medication. “It didn’t help me be productive at all.”

Because it had been a decade since Shannon had tried Adderall the first time (she’s 41 now), she suspected her body’s chemistry had changed. After trying generic Adderall for six weeks, her doctor prescribed generic Vyvanse (lisdexamfetamine dimesylate) instead.

For the first four months, the generic Vyvanse seemed to help. But after filling her prescription at a different pharmacy while traveling, Shannon recalls, “it was like I was taking candy.”

On occasion, Shannon mistakenly doubled her dose, forgetting she’d already taken it. But taking twice as much as she should “didn’t make any difference at all,” she says.

Shannon says that if she ever got a refill that did seem to work, it seemed to wear off hours before it was supposed to. Her spiraling thoughts would flood back, she says. “I just had to wait until the next morning or work my schedule around it” to get things done.

One month, Shannon says she paid out of pocket for brand-name Vyvanse, which seemed to help. But when she switched back to generic, she started having panic attacks.

Shannon and her doctor have filed 16 appeals with her insurance company in an effort to get brand-name Vyvanse covered. In the meantime, she paid about $200 in September for just two weeks’ worth of the brand-name drug, while filling the rest of her prescription with the generic. To help her cope, her doctor has advised alternating between the brand-name and generic pills each day, so she wouldn’t spiral after taking the generic for several days in a row.

Meggan’s Son

Diagnosis: Autism
ADHD Stimulant Prescribed: Concerta (extended-release methylphenidate)

For the first two months that her son took Concerta, Meggan says he received the brand-name version. For month three, he was given a generic.

“It seemed like it wasn’t lasting as long,” says Meggan. “It was only lasting like six hours, and by the afternoon, he was really struggling to sit still and remain focused at school.”

His doctor raised his dosage, but Meggan soon discovered that the generic relies on a different extended-release mechanism than the brand-name drug, so it doesn’t always last as long. She brought that information to her doctor.

Now, Meggan says her son gets only the brand-name Concerta.

“The pediatrician was clearly not educated on the difference between brand name and generic,” she says.

Kacie

Diagnosis: ADHD, Narcolepsy
ADHD Stimulants Prescribed: Adderall ER, Concerta, Vyvanse

While Kacie was initially diagnosed with ADHD as a child, she didn’t start taking medication until her sophomore year in college. Once that happened, her grade point average jumped from about 2.4 to 3.6, she says. “[The medication] was like a miracle worker in a lot of ways.”

Over the years, Kacie says she’s tried brand-name and generic versions of extended-release Adderall (amphetamine/dexamphetamine salts), Concerta (extended-release methylphenidate), and Vyvanse (lisdexamfetamine dimesylate). At times, she was prescribed immediate-release Adderall  as an add-on when her extended-release medication wore off.

For the past decade, Kacie says she has relied on a combination of Vyvanse and immediate-release Adderall. The “crashes” she experiences when the extended-release drug fades are especially severe, she says, leaving her exhausted and unable to function — because she also lives with narcolepsy.

Since the stimulant shortage started in 2022, Kacie says things have gotten worse. She’s been given generic Adderall  made by seven different manufacturers.

There have been notable issues. The Teva-manufactured generics she received in June 2025 wore off far too quickly, she says. “I don’t know if it’s something they add, but for whatever reason, I just metabolize it differently.”

Kacie used to work full-time, but in May 2024, she had to pull out of a consulting contract because she says she wasn’t able to complete the work she’d promised. “Right now, I don’t have any consulting clients, because I’m trying to figure out the med stuff,” she says.

Complications continue for Kacie. A few months ago, in August 2025, her Adderall  prescription was filled with medication from a manufacturer she’d never received before, Oryza Pharmaceuticals. Although she’s prescribed 30 mg, her doctor has always instructed her to split each pill and take it in two doses. But when she tried this with her meds from Oryza, the tablet didn’t break cleanly along the scored line; it crumbled. “I’m losing medication every time I split it,” she says.

Bridget

Diagnosis: ADHD
ADHD Stimulant Prescribed: Adderall

Shortly after being diagnosed with ADHD in 2005, Bridget noticed that certain generic forms of Adderall seemed to work better for her than others. Some caused side effects such as headaches, anxiety, and fatigue. But when there were no shortages, it was easy for her to track down Teva, the manufacturer that had worked well for her. When the shortages hit in 2022, Bridget says she was filled with anxiety, wondering if her medication would work with each refill. “I had to basically take whatever generic was available that month from whatever pharmacy had it in stock.”

Bridget notes with frustration that even the Teva-made version, which had once been reliable, now feels different. Pills that used to break cleanly so that she could take half of an instant-release pill multiple times a day are now crumbling in her hands. More importantly, the medication no longer seems as effective as it had been before.

“It’s hard to tell if the changes I’m experiencing now are solely due to the medication or my own body cycles,” Bridget says. “I’m perimenopausal, which creates a whole new set of variables. Is my drug not working correctly, or are my hormones changing?”

Casey

Diagnosis: ADHD
ADHD Stimulants Prescribed: Vyvanse, Adderall

Casey was first prescribed Vyvanse as a high school sophomore, but when she entered college two years later, her insurance stopped covering it and she was switched to Adderall. She remained on brand-name Adderall (amphetamine/dexamphetamine salts) for about nine years, until August 2022.

When the ADHD medication shortage began, Casey says she started receiving generic extended-release Adderall made by different manufacturers. She says she thought the drugs would be the same as the brand-name, but instantly noticed problems: She couldn’t concentrate. She was constantly bloated and gained 20 pounds. “I became extremely moody and unpleasant to be around.”

Worse, her grades suffered so severely that she says she lost a $90,000 law school scholarship.

In one particularly noticeable instance, Casey says she was switched from generics   made by Camber to drugs made by Lannett, and “lost over 20 pounds in a single month.”

Today, Casey says she pays $200 per month out of pocket so she can have name-brand Adderall. “I am familiar with the side effects and know how to manage them properly. I’m healthy and happy now that I know the problems I was experiencing were due to a medication change, and not because there’s something wrong with me,” she says.

What You Can Do if Your Generic Medication Doesn’t Seem to Be Working

Are you noticing issues with your generic ADHD medications? You’re not alone, and not imagining it. Experts recommend the following:

• Do your best to keep track of how and why your medication isn’t working. Gina Pera, an author and ADHD educator, suggests keeping an hour-by-hour log including tasks you’re able to complete shortly after taking the medication that you’re no longer able to do hours later, if you suspect the medication is wearing off too quickly.
• Submit your experience to MedWatch, the FDA-run database that collects reports of drug reactions from patients, physicians, and caregivers. The FDA monitors these reports, and if a large number of reports suggest that a specific generic medication isn’t working as it should, they may initiate testing and potentially downgrade the therapeutic equivalence codes or even remove certain drugs from the market if they are found to be unsafe. Provide as many details as possible in your report.
• Talk to your doctor about requesting that your insurance company cover the brand-name medication if you’re struggling with generics. The process doesn’t always work, and even when it does, there may still be extra costs, but it’s an option worth exploring.
• Remember to keep up with all the non-drug ADHD management strategies you can, such as organizational tools that support executive function, and doing everything you can to get good enough sleep.