Breast Cancer, HRT
Women with a prior hysterectomy given estrogen-only HRT (conjugated equine estrogen) had a 23% reduction in breast cancer diagnosis compared to those assigned placebo. The 10,000 women were followed for more than 16 years. This was reported at the San Antonio Breast Cancer Symposium (SABCS) based on the Women’s Health Initiative (WHI), a long-term study of thousands of women covering many health measurements. That same group of women had 44% fewer breast cancer deaths compared to the placebo group.
A second group of 16,000 women who still had their uterus found that those who got estrogen (the conjugated equine estrogen) plus progestin (in the form of medroxyprogesterone acetate) had a 29% higher rate of breast cancer and a higher death rate from breast cancer than those on placebo after more than 18 years of cumulative follow-up.
There are several observational studies (lower quality research) that conflict with these results. Bioidentical HRT was not included in the study.
- HRT Has 20-Year Impact on Breast Cancer Risks – MedPage Today, Dec 13, 2019
From Stat: “As many as 43% of antibiotic prescriptions in the U.S. could be inappropriate, according to a study in BMJ. The researchers used official diagnostic codes to identify whether each antibiotic prescription was accompanied by appropriate, inappropriate, or no documented indication. According to their criteria, 57%, or around 74 million, prescriptions were deemed appropriate, while 25%, or about 32 million, were considered inappropriate, and 18%, or around 24 million, lacked either an appropriate or inappropriate documented indication.”
- Antibiotic prescribing without documented indication in ambulatory care clinics: national cross sectional study – BMJ, Dec 11, 2019
After using Vivitrol the patient’s previous level of tolerance for opioids lowers unpredictably. Therefore if an addict using Vivitrol relapses and takes an opioid (legal or illegal) in the same amounts as before treatment, the patient is at high risk of overdosing. That’s not an uncommon side effect, “Caregivers often provide similar warnings to former users who get off opioids in rehab or while incarcerated” Washington Post article. However, the manufacturers of Vivitrol neglected to include this warning in it’s packaging and healthcare literature. The FDA is requiring an immediate fix.
- FDA warns company over ad that leaves out information on risk of overdose – Washington Post, Dec 11, 2019
- FDA blasts Alkermes for underselling the risks of opioid addiction drug Vivitrol – Stat