Prostate, Hair Loss Drug Linked to Risk of Diabetes, High Cholesterol

Prostate, Hair Loss Drug Linked to Risk of Diabetes, High Cholesterol

A widely used drug to treat enlarged prostate — and off-label to treat hair loss — may increase a man’s risk for diabetes, high cholesterol and fatty liver disease. It may also worsen erectile dysfunction.

Avodart (dutasteride) is approved to treat benign prostatic hyperplasia (BPH), the medical term for an enlarged prostate. In a retrospective study, researchers looked back at 2 groups of men with BPH for between 3 and 3.5 years. One group was prescribed Avodart and the other Flomax (tamsulosin), a different kind of prostate medication. Avodart works by reducing the size of the prostate, while Flomax relaxes the prostate muscle.

Compared to the Flomax group, those taking Avodart had higher blood sugar and lipid levels, and reported worse sexual function, the researchers wrote in the journal Hormone Molecular Biology and Clinical Investigation.

“In order to reduce the negative impact on overall health and quality of life, physicians need to discuss with their patients the potential adverse side effects of taking Avodart,” corresponding author Abdulmaged M. Traish, MBA, PhD, of the Boston University School of Medicine said in a statement.

As we’ve reported in the past, if you do suffer from BPH and you and your physician have determined medication is necessary, Consumer Reports recommends the generic drug doxazosin as a first-line treatment. If your doctor determines a combination of drugs is necessary, the magazine recommends Proscar (finasteride), which is also available as a generic.


Jonathan Block

Jonathan Block

Jonathan Block is an associate editor at BioCentury, which provides news and information about the biotechnology and pharmaceutical industries. Prior to joining BioCentury in 2019, Jonathan worked for MedShadow as content editor. He has been an editor and writer for multiple pharmaceutical, health and medical publications, including The Pink Sheet, Modern Healthcare, Health Plan Week and Psychiatry Advisor. He holds a BA from Tufts University and is earning an MPH with a focus on health policy from the CUNY Graduate School of Public Health & Health Policy.


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