Covid-19: Side Effects of Trump’s Treatments

Inactive Ingredients
Emma Yasinski
Emma Yasinski Staff Writer
Last updated:

President Donald Trump announced (via Twitter, of course) what some considered unthinkable, and others considered inevitable — that he had tested positive for Covid-19. Over the weekend, he received various treatments  — supplements like vitamin D, zinc and melatonin, an experimental antibody combination, an antiviral drug and a powerful anti-inflammatory steroid. Trump was already known to be on daily medications like statins. Many doctors have pointed out that such an aggressive treatment strategy is unlike any you’d receive as an average patient. Trump’s recent regimen is called VIP Treatment, which is special care offered only to very famous or wealthy patients. Despite the name, this course of treatment isn’t always a positive for the patient.

Sometimes it means that an individual receives more treatments than he or she needs. These treatments could be helpful, but each drug or supplement has its own risks and side effects. Plus, there could be a host of interactions. “Some of the interactions are just not known since the monoclonal antibodies and remdesivir [which Trump received] are still experimental drugs,” Kevin Kavanagh, MD, tells MedShadow.

So what do we know about the potential downsides to the various treatments the president has received?


  1. Dexamethasone

Dexamethasone — a decades-old oral corticosteroid commonly used to treat inflammatory diseases — is the most well-studied of the treatments administered to Trump as the result of his Covid-19 diagnosis. Clinical trials for Covid-19 have shown it to help patients with severe disease. Kavanaugh told Health Watch USA that the treatment suppresses the immune system — a positive if an overactive immune response is wreaking havoc on the body, but dangerous if the patient’s immune system is working normally. Additionally, the drug’s side effects can mask symptoms while patients are still sick.

On their own, steroids like dexamethasone have the potential to produce a wide range of side effects from high blood pressure to blurry vision and upset stomach. In many patients, dexamethasone boosts energy and causes euphoria, both of which could hide COVID-19 symptoms like fatigue. In terms of an altered mental state, Kavanagh warns, “the steroids are known to cause anywhere from an euphoria to frank psychosis [a condition characterized by delusions in which a person can lose touch with reality]. Almost everyone on high dosages suffers a degree of this [side effect]. In addition, one also can experience a psychological crash when one comes off of steroids.” 

Dexamethasone’s long-term effects should be taken into consideration by your doctor when prescribed. It can cause spikes in blood sugar leading to diabetes, a concern in an older man like President Trump who is overweight. It can also result in bone weakening, not as likely a problem for a man, but an older woman with thinning bones might need to be concerned. 

The side effects of dexamethasoneat least when taken for other conditionsmay be well-characterized, but we know considerably less about the other treatments the president has received.

  1. Remdesivir

Remdesivir, developed to treat hepatitis C and then later used for Ebola, was the first drug the FDA authorized for use in Covid-19 patients through an emergency-use authorization on May 1. This means that the drug is temporarily available to Covid-19 patients, even though it has not yet been evaluated through normal FDA approval pathways.

Data from a clinical trial published in JAMA in August showed that the antiviral drug may shorten Covid-19 recovery time and it can cause headaches, nausea and hypokalemialow levels of potassium that lead to muscle cramps, weakness, constipation and in serious cases, heart arrhythmias.

Robert Solomon, MD, FACEP, an emergency medicine physician at the University of Pittsburgh Medical Center, explains that drugs similar to remdesivir have given patients, “elevated liver enzymes suggesting the possibility of liver damage.” The president is known to take daily statins to reduce his cholesterol, which can also damage the liver. “We have no idea if this effect from both drugs could be additive or even synergistic,” he adds.

  1. Regeneron Antibody Cocktail

 The treatment is called a “cocktail” because it contains two different antibodies that are both thought to prevent the virus from entering cells. This particular combination of antibodies is new, but the concept of using antibodies to help treat infections is not. It is still in clinical trials, though early data released in June suggested that the side effects of the treatment, which is designed to mimic the body’s own immune response, were minimal. 

  1. Aspirin

In addition to treating pain and lowering fevers, aspirin taken daily may help reduce the risk of blood clots and heart attacks — one of the most serious dangers of Covid-19, but a well-known side effect is gastrointestinal bleeding.

  1. Famotidine/Pepcid

 A very small study suggests that the antacid can help ease symptoms of Covid-19. When taken only short-term, the drug has minimal side effects, including dizziness and occasional racing heartbeat, dry skin, insomnia, gastrointestinal symptoms and temporary forgetfulness. 

  1. Vitamin D

President Trump also received three supplements early in the course of his treatment: vitamin D, zinc and melatonin. According to Solomon, all three fall into the category of “unlikely to be harmful and might help.” Some studies have suggested that patients who are vitamin D-deficient have worse Covid-19 outcomes. However, there is no evidence to suggest that more vitamin D is better if you already have healthy levels, and there are downsides to taking too much, like an increased risk of kidney stones. It may also interfere with the efficacy of statins.

  1. Zinc

Zinc is often taken to shorten the duration of the common cold. It’s “known to inhibit viral replication in certain other contexts,” says Solomon. It’s unclear if it can help with Covid-19, but taking too much can lead to gastrointestinal side effects like nausea.

  1. Melatonin

Melatonin, which is commonly used as a sleep aid, may help reduce inflammation associated with an overzealous immune response. It may also produce mild side effects like headache, dizziness and nausea, according to a Cochrane review. 

In appropriate doses, the supplements may not be too dangerous, but “using all three [Covid-19 drugs] certainly increases the likelihood of interactions,” Solomon says, even if it isn’t necessarily clear what these interactions might be just yet. What we do know is that dexamethasone especially, may have an impact on President Trump’s personality, his long-term health, or both.



DISCLAIMER: MedShadow provides information and resources related to medications, their effects, and potential side effects. However, it is important to note that we are not a substitute for professional medical advice, diagnosis, or treatment. The content on our site is intended for educational and informational purposes only. Individuals dealing with medical conditions or symptoms should seek guidance from a licensed healthcare professional, such as a physician or pharmacist, who can provide personalized medical advice tailored to their specific circumstances.

While we strive to ensure the accuracy and reliability of the information presented on MedShadow, we cannot guarantee its completeness or suitability for any particular individual's medical needs. Therefore, we strongly encourage users to consult with qualified healthcare professionals regarding any health-related concerns or decisions. By accessing and using MedShadow, you acknowledge and agree that the information provided on the site is not a substitute for professional medical advice and that you should always consult with a qualified healthcare provider for any medical concerns.

Was This Article Helpful?

Staff Writer
Show Comments (9)
0 0 votes
Article Rating
Notify of
Most Voted
Newest Oldest
Inline Feedbacks
View all comments

zinc is used with a substance to enable it’s absorbtion, quercetin does this I think. you can investigate this and give the info please. maybe its the hydroxychloroquine that acts as the transmitter ?
Dr. Solomon basically has no idea so why quote him ? many medicines affect liver, kidney, heart, everything.
vitamins are like everything else, a double edged sword. depends on the dosage, the individual, the doctor’s intelligence in weighing factors. like every other treatment.
good information otherwise
but pretty anti-Trump biased, speculating on his personality, etc. steroids are used widely for many diseases. please leave political opinions separate from medical focus. Be careful how you couch things. its a good website and its good to know about side effects. Be sure to be independent and not a voice for the FDA and the AMA and the WHO approved information……..are you ?

Ren Diotha

Here I was, thinking I found a nice, neutral article on a topic of interest. And you couldn’t help it, could you? Had to enter the political snark. Way to alienate over fifty percent of your readers, right out of the gate. At least. There are those who maybe support their President, and those who are entirely sick of exactly this kind of thing. If you’re going to be a political rag, rename the page.

Robert Eredics R.Ph.

He should have had Ivermectin! Stat. !
For you – you are easy to fool, and much harder to convince you have been fooled (how did the cool-aid taste) You will see the light sooner than you expect.

Barbara Johnston

Just another political hit piece pretending to be medical information. Another non-trustworthy site. Especially, when you left out the side effect of DEATH in the vaccine effects chart in the other article. Even VAERS lists about 15,000 killed by the experimental injection pretending to be a vaccine. Along with that, the HPV vax has debilitated hundred if not thousands of young girls already. Money grubbing Big Pharma couldn’t care less.

Factious Doctors

Literally every thing said in this article is opposite from the reality of the facts about covid and these treatments. Exception is the only treatment that was approved is extremely dangerous and is the only one being used to kill people (Remdesivir) kidney killer!

Would love your thoughts, please comment.x