Diabetes Drug May Also Help Kidney Disease

Diabetes Drug May Also Help Kidney Disease

A diabetes drug may also help people with kidney disease by reducing the risk of experiencing kidney failure.

The drug, Invokana (canagliflozin), is known as an SGLT2 inhibitor. In a new study, published in the New England Journal of Medicine, patients with diabetes and chronic kidney disease taking Invokana and either an angiotensin-converting enzyme (ACE) inhibitor or an angiotensin receptor blocker (ARB) saw a 30% drop in kidney failure rates compared with those taking an ACE inhibitor or ARB alone. ACE inhibitors and ARBs are considered standard care for kidney disease.

Results also showed Invokana reduced heart failure by over 30%, and significant cardiovascular events by 20%. Hospitalization due to heart failure was also reduced by nearly 40%.

The study, dubbed CREDENCE, enrolled 4,400 patients from 34 countries. There was no increased risk of side effects seen in the Invokana group.

CREDENCE was sponsored by Janssen, the manufacturer of Invokana. The drug has a boxed warning about a risk of lower limb amputation.


Jonathan Block

Jonathan Block

Jonathan Block is an associate editor at BioCentury, which provides news and information about the biotechnology and pharmaceutical industries. Prior to joining BioCentury in 2019, Jonathan worked for MedShadow as content editor. He has been an editor and writer for multiple pharmaceutical, health and medical publications, including The Pink Sheet, Modern Healthcare, Health Plan Week and Psychiatry Advisor. He holds a BA from Tufts University and is earning an MPH with a focus on health policy from the CUNY Graduate School of Public Health & Health Policy.


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