Off Label
Off label refers to the unapproved use of an approved drug, often to manage conditions for which no specific or adequate treatment exists. This practice…
Dec 4, 2025
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Shedding Light on the Risks
& Benefits of Medications
Shedding Light on the Risks
& Benefits of Medications
Drug Safety
Box warning
Box warnings, commonly referred to as “black box warnings,” are the strongest warnings issued by the FDA, indicating that a medication may cause serious or…
Dec 4, 2025Generic Drugs
A generic drug is a medication designed to match an approved brand-name drug in almost every way: dosage form, safety, strength, route of administration, quality,…
Nov 18, 2025Biosimilar
A biosimilar is a biologic medicine that has been developed to closely match an existing FDA-approved biologic. Both biologics and biosimilars are products made from…
Nov 15, 2025Pharmaceutical pollution
Drugs can get into our waterways through wastewater (in our urine) and improper disposal of unused drugs, causing pharmaceutical pollution. At trace amounts, pharmaceuticals have…
Oct 13, 2025Comorbidity
Comorbidity refers to the presence of one or more health conditions alongside a primary condition. For example, if someone has diabetes but also experiences high…
Oct 13, 2025Polypharmacy
When someone is taking five or more medications on a regular basis, this is called polypharmacy. The United States has one of the highest rates…
Oct 8, 2025Pharmacovigilance
According to the World Health Organization (WHO), pharmacovigilance describes the science and efforts behind drug safety. This includes drug testing in clinical trials and the…
Oct 8, 2025Overprescribing
Overprescribing means prescribing a drug (or drugs) when it’s not clinically necessary. This can lead to increased side effects and public health issues. A 2018…
Oct 8, 2025Drug Cascades
Also known as “prescribing cascades,” drug cascades occur when a medication is prescribed to treat the side effects of an original drug you are on.…
Oct 8, 2025Disease Mongering
Sometimes referred to as “selling sickness,” disease mongering is when pharmaceutical companies (sometimes working with healthcare professionals and patient groups) overstate the severity of minor…
Oct 8, 2025Deprescribing
Deprescribing is when a physician reduces a medication to the lowest effective dose, or discontinues it altogether. This typically occurs when a patient’s condition changes…
Oct 8, 2025Contraindication
When a drug or medical procedure could harm a patient, the advice not to use it is called a contraindication. There are two kinds of…
Oct 8, 2025Adverse drug events (ADE)
ADEs are when a medication leads to a negative or harmful effect. ADEs are responsible for more than 1.5 million emergency room visits each year…
Oct 8, 2025