Morning Sickness Drug May Be Ineffective

Morning Sickness Drug May Be Ineffective

A medication commonly prescribed for morning sickness may not be effective, according to a new report published in the journal PLOS ONE. Canadian researchers reported that the drug, Diclegis (doxylamine and pyridoxine), did not show a clinically important benefit during the trial period, and suggest that the FDA re-evaluate its approval.

The research team examined the 9,000-page clinical study report submitted by Duchesnay Inc., the drug’s manufacturer. Duchesnay’s clinical trial examined 187 women over a 2-week time period and had set a goal of improving symptoms by 3 points on a 13-point scale. However, the study’s results showed that Diclegis had only resulted in a 0.73-point improvement.

Despite the reanalysis, the American College of Obstetricians and Gynecologists (ACOG) — one of the nation’s leading medical associations — still insists that Diclegis “is safe and effective and should be considered first-line pharmacotherapy.”


Alanna McCatty

Alanna McCatty

Alanna McCatty is founder and CEO of McCatty Scholars, an organization that devises and implements financial literacy programs for students to combat the nationwide issue of the loss of educational opportunity due to the ramifications of burdensome student debt. At MedShadow, she reports on new findings and research on the side effects of prescription drugs. She is a graduate of Pace University.


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