Popular Overactive-Bladder Drug Linked to Dementia

Popular Overactive-Bladder Drug Linked to Dementia

Men who take a drug that accounts for more than one-quarter of all the prescriptions to treat overactive bladder (OAB) run the risk of developing dementia.

The drug, oxybutynin, is widely prescribed as a generic drug, but is also known under its brand name, Ditropan. Researchers in the UK found that those who took the medication for more than 3 years were 54% more likely to develop dementia within 10 years. The results of the study were just presented at the European Association of Urology’s annual conference.

“Doctors need to look closely at the levels of prescribing,” Daniel Pucheril, MD, of Henry Ford Hospital in Detroit, who headed the research, told the Daily Mail. “Doctors need to look closely at the levels of prescribing. Despite evidence of side effects, physicians are not commonly checking for cognitive effects in those using these medications.”

Oxybutynin accounts for 27% of all OAB prescriptions in the US. Although there are many OAB drugs available, oxybutynin is popular because it is generic, and far cheaper than newer, brand-name drugs.

Oxybutynin belongs to a class of drugs known as anticholinergics, which includes antidepressants, antihistamines and antipsychotics. Long-standing evidence has found that anticholinergics can negatively influence cognition.


Jonathan Block

Jonathan Block

Jonathan Block is an associate editor at BioCentury, which provides news and information about the biotechnology and pharmaceutical industries. Prior to joining BioCentury in 2019, Jonathan worked for MedShadow as content editor. He has been an editor and writer for multiple pharmaceutical, health and medical publications, including The Pink Sheet, Modern Healthcare, Health Plan Week and Psychiatry Advisor. He holds a BA from Tufts University and is earning an MPH with a focus on health policy from the CUNY Graduate School of Public Health & Health Policy.


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