Acid Reflux Drugs Tied to Higher Kidney Disease Risk

An analysis of an FDA side effects database has found that taking proton pump inhibitor (PPI) drugs such as Prilosec (omeprazole) and Nexium (esomeprazole), used to treat acid reflux, is associated with an increased risk of kidney disease.

Researchers examined data from the FDA Adverse Event Reporting System (FAERS) database. They narrowed their study to reports on 43,000 people who took a PPI and no other medications and 8,000 people who took histamine-2 receptor antagonists (H2 antagonists), another class of acid-reducing drugs that includes Pepcid (famotidine) and Zantac (ranitidine).

Results, published in Scientific Reports, found that those who took only PPIs were 28.4 times more likely to have chronic kidney disease, 35.5 times more likely to report end-stage renal disease and 4.2 times more likely to have acute kidney disease compared to those on H2 antagonists.

“Although [H2 antagonists] have not been shown to be as effective as PPIs, they might be considered as alternatives for patients who are at high risk for developing renal and electrolytes imbalances,” the researchers concluded.

A 2017 study also found that long-term use of PPIs can lead to kidney damage.


Jonathan Block

Jonathan Block

Jonathan Block is MedShadow's content editor. He has previously worked for Psychiatry Advisor, Modern Healthcare, Health Reform Week and The Pink Sheet.


Did you find this article helpful?


Latest News

News Scan: Warfarin, A-Fib, Lavender Oil and Dopamine Agonist Medicine

News Scan: Warfarin, A-Fib, Lavender Oil and Dopamine Agonist Medicine

Every so often a lay person like me slaps her forehead and says out loud, “what took so long?” A veggie works better than a medicine, why not use the veggie? Talking to patients in their home leads to better understanding by the patients? Of course. And less intuitive but…

News Scan 9/4/2019: Breast Cancer, Osteoporosis and Cardio Health

News Scan 9/4/2019: Breast Cancer, Osteoporosis and Cardio Health

Less medicine and a little less food are the themes for keeping healthy this week.  Be well.    Breast Cancer and Hormone Treatment In a large study of published studies (meta analysis) that included more than 100,000 women, those who reported ever using MHT had a 26% higher relative risk…