Experimental Peanut Allergy Drug Shows Promise, But With Side Effects

Experimental Peanut Allergy Drug Shows Promise, But With Side Effects
Experimental Peanut Allergy Drug Shows Promise, But With Side Effects

First Peanut Allergy Treatment Drug

An experimental treatment that could become the first drug to treat severe peanut allergies is generating a lot of media buzz due to positive trial results, though a closer look at the data reveals that the drug has some considerable side effects.

Results for the the drug, AR101, were published Sunday in the New England Journal of Medicine, and found that about two-thirds of the children given the medication were able to eat about 600 milligrams of peanut protein – roughly equivalent to two peanuts – without having an allergic reaction. By comparison, only 4% of the children given a placebo were able to tolerate the peanut after a year.

The trial, which enrolled 551 children, nearly all of whom were between 4 and 17 years old, was funded by Aimmune Therapeutics, AR101’s developer. The drug, which is actually made from peanut flour, is designed to work by gradually desensitizing a child to the peanut allergy.

Results showed that 20% of the children who were in the AR101 group dropped out of the study, and more than half this number was due to adverse events. In addition, 14% of those on active treatment needed an injection of epinephrine, a medication used in emergencies for those experiencing severe allergic reactions. In the placebo group, just 6.5% of participants required epinephrine.

More children in the AR101 group experienced serious adverse events compared to those taking a placebo. The most common side effects experienced were abdominal pain, vomiting, itching and nausea.


DISCLAIMER: MedShadow provides information and resources related to medications, their effects, and potential side effects. However, it is important to note that we are not a substitute for professional medical advice, diagnosis, or treatment. The content on our site is intended for educational and informational purposes only. Individuals dealing with medical conditions or symptoms should seek guidance from a licensed healthcare professional, such as a physician or pharmacist, who can provide personalized medical advice tailored to their specific circumstances.

While we strive to ensure the accuracy and reliability of the information presented on MedShadow, we cannot guarantee its completeness or suitability for any particular individual's medical needs. Therefore, we strongly encourage users to consult with qualified healthcare professionals regarding any health-related concerns or decisions. By accessing and using MedShadow, you acknowledge and agree that the information provided on the site is not a substitute for professional medical advice and that you should always consult with a qualified healthcare provider for any medical concerns.

Was This Article Helpful?

Show Comments (0)
0 0 votes
Article Rating
Notify of
Inline Feedbacks
View all comments
Would love your thoughts, please comment.x