Children who are prescribed a popular ADHD (attention deficit/hyperactivity disorder) stimulant may be at risk of experiencing hallucinations or other types of psychotic events, according to a meta-analysis.
Treatment of ADHD with Methylphenidate
Danish researchers examined 10 randomized controlled trials and 17 nonrandomized studies that included more than 77,000 participants looking at treatment of ADHD with methylphenidate. Ritalin, Concerta and Daytrana are some brand-name versions of the stimulant.
Results indicated that methylphenidate may cause psychotic symptoms in between 1.1% and 2.5% of those taking the drug, researchers reported.
The researchers, however, cautioned that there is not definite proof of a link between methylphenidate and an increased risk for psychotic symptoms as the data in the studies was not of ideal quality.
The authors conclude that doctors, patients and their caregivers should be aware of the possibility of psychotic symptoms while taking methylphenidate.
A separate meta-analysis published in The Lancet Psychiatry found that methylphenidate is the safest and most effective ADHD medication for short-term – 12 weeks – ADHD treatment. While methylphenidate was likely to lead to weight gain in children, it was also the only drug with better acceptability than placebo. Researchers noted that more studies are needed to confirm the longer term effects of ADHD medications.
