Many Clinical Trials Often Absent From Journals

Clinical trial results are almost always listed in government sources, but many never make it into published literature, where they would have much greater exposure. The authors of a new research letter, published in JAMA Internal Medicine, noted that the exclusion of certain clinical trial results, which provide scientific data on a drug, leaves “a distorted body of public evidence.”

In order to assess the availability of clinical trial results in the public domain, researchers evaluated the availability of results in PubMed-cited publications and/or results posted in Clinicaltrials.gov.

The study consisted of 329 trials studying 86 drugs and representing 96 unique sponsor-drug-condition trial sets.

The results found that Clinicaltrials.gov consisted of nearly one-quarter of sampled drug trials and more than one-tenth of sampled sponsor-drug-condition trial sets. However, results remain unavailable in Clinicaltrials.gov or PubMed 7 or more years after study completion for nearly one-quarter of sampled drug trials and more than one-tenth of sampled sponsor-drug-condition trial sets.

“Systematic reviewers who rely entirely on literature searches are at risk of missing relevant evidence,” the authors wrote.


Alanna McCatty

Alanna McCatty

Alanna McCatty is founder and CEO of McCatty Scholars, an organization that devises and implements financial literacy programs for students to combat the nationwide issue of the loss of educational opportunity due to the ramifications of burdensome student debt. At MedShadow, she reports on new findings and research on the side effects of prescription drugs. She is a graduate of Pace University.


Did you find this article helpful?


Latest News

FDA Recalls Metformin and NP Thyroid

FDA Recalls Metformin and NP Thyroid

The FDA has issued a recall of two drugs–NP Thyroid and Metformin–after testing revealed that they weren’t up to code. Read more below, and if you’re taking either medication, please be sure to contact your doctor for how to continue treatment responsibly.  NP Thyroid Recalled Thirteen lots of NP Thyroid,…

Can Convalescent Plasma Treat COVID-19 Patients?

Can Convalescent Plasma Treat COVID-19 Patients?

One of the most promising treatments for COVID-19 is convalescent plasma, a component of blood. People who have been infected with the virus and are now healthy have developed COVID-19-fighting antibodies, which, the theory is, can be given to people currently sick with COVID-19 so that those antibodies can boost…

  • Advertisement