We seek to create a world where there are safer medications for all and where all people are fully informed about their medication benefits and side effects, using our explanatory and investigative journalism to both inform and stimulate public discussion to drive toward solutions.
Sleep Disorders
The most effective treatment for sleeplessness causes none of the side effects that sleep medications do
October 29, 2025
Drug Safety
Marketed as a safer alternative to smoking, Zyn and other oral nicotine pouches are hooking a new generation of users, and may be causing side effects not yet fully understood
October 16, 2025
Supplements
Despite its widespread use, vitamin D remains one of the most hotly debated nutrients in medicine, especially when it comes to dosing, safety, and benefits
August 5, 2025
Drug Safety
Insurers say it saves money. Patients and doctors say it causes harm. Inside the growing controversy over step therapy
July 21, 2025
Antidepressants
P. began taking Zoloft — an antidepressant known generically as sertraline —...
July 9, 2025
Hormone Therapy
Outdated studies, variations in doses and formulations, and individual health factors all play a role in the absence of a straightforward answer about the risks of HT
April 10, 2025
cannabis
While marijuana can provide relief from pain and sleeplessness for many, its side effects are deeply nuanced, shaped by factors such as potency, duration of use, methods of consumption, and the risk of dependence
February 6, 2025
vaccines
Trying to find detailed information on side effects proved harder than I had imagined. It shouldn’t be this way
October 22, 2024Independent, science-based journalism delivered directly to your inbox.
The latest FDA updates on medication recalls, manufacturing violations, and quality concerns that could affect your prescriptions.
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Interactions to watch between common prescription drugs and supplements.
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Yes, many people can safely take Tylenol and Advil together to treat short-term pain or fever. But before combining them, ask yourself: Do I really need both?
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Combining St. John’s wort with Lexapro can amplify the risk of side effects, including the potentially serious condition known as serotonin syndrome.
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Before combining Excedrin and Wellbutrin, it’s crucial to consider potential side effects, such as increased irritability, nervousness, and seizures in susceptible individual
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Supplements
Researchers are curious about this traditional remedy, but say better quality studies are needed to confirm its efficacy and safety.
December 4, 2025
Drug Safety
The FDA approved a second non-hormonal hot-flash drug in October. Here’s what the clinical trials can tell us about it
December 2, 2025
Drug Safety
Most over-the-counter medications were never tested for bioavailability or bioequivalence, leaving key questions unanswered about how well they work
November 19, 2025
Drug Safety
A government warning has raised new questions, but the evidence is mixed and misunderstood
September 25, 2025
Drug Safety
The FDA’s drug recall system is meant to protect consumers, but inspection blind spots, manufacturing lapses, and slow communication can leave dangerous medications in circulation for months
August 27, 2025
Female Sexual Dysfunction
Marketed as a breakthrough for low libido in women, flibanserin’s approval followed two FDA rejections, a controversial campaign, and safety concerns
June 6, 2025
Statins
Statins lower cholesterol, but do they always protect against heart disease? Weighing the risks, benefits and side effects
May 23, 2025
Obesity
From breakthrough results to difficult side effects, real patients share what it’s like to use GLP-1 medications
May 15, 2025I started MedShadow Foundation in 2013 because I was harmed by a medicine called DES (diethylstilbestrol) that was given to my mother when she was pregnant with me. When I was 13, I learned that I would not ever be able to get pregnant because of the side effects of DES. The FDA told doctors to stop prescribing that drug to pregnant women in 1971, but between five and 10 million pregnant women had already been given it.
I’ll take medicine when I need to, but because of DES, I’m very hesitant. Instead, I pay close attention to eating whole foods and exercising regularly so that my immune system and my body are healthy. Not taking any drugs (when possible) is the best way to avoid harmful side effects.
Soon after I started MedShadow, DES Action approached me about taking over the management of their member organization. DES Action USA has been the leading advocate for those exposed to DES for more than 40 years.
Because of my work with MedShadow, I’ve learned a lot about how the FDA approves drugs. In 2017 I applied to and was appointed to the FDA Advisory Committee on Drug Safety and Risk Management. I joined a panel of doctors and pharmacists as the lone consumer representative. I’m so excited to have a seat at the table when the FDA is deciding if a drug is safe and effective enough to approve.